The phenotypic variability of amyotrophic lateral sclerosis. Neural stem cell-based treatment for neurodegenerative diseases. Racing against the clock: recognizing, differentiating, diagnosing, and referring the amyotrophic lateral sclerosis patient. MSC also have the potential to regulate inflammation, mainly by releasing signalling molecules that affect other cells. Neurotrophic factors are small molecules, that support the growth, survival and development of neurons. Mechanisms of action for MSCs after transplantation in ALS, include promoting the formation of neurons, reducing cell death, reducing free radical levels, stimulating synaptic connections from damaged neurons, and releasing various neurotrophic factors. Risk benefit was favourable in all groups. Regarding disease progression, three types of response were measured with ALSFRS-R, decreased progression (n=21, 31.3 %), no change in progression (n=33, 49.3 %) and increased progression (n=13, 19,4 %). What distinguishes the participants in the subgroups are demographic and clinical factors. The median survival increased to twice in all subgroups of patients treated with mesenchymal stem cells. Results from this study confirm previously published ALS studies showing the safety and/or efficacy of MSC administration in smaller studies 5-8,11-13. The survival time was followed up until March 2020. Patients were assessed using the ALSFRS-R scale. The effect of the treatment was studied in the form of progression of the disease and survival time. The 67 patients in the group who received treatment received three intrathecal injections with 30×10^6 MSCs every two months. The patients in the treatment and control group were matched in terms of gender, symptoms, ethnicity, stage of disease at the beginning of the treatment, and ALS medication. The participants were 67 patients who received treatments with MSCs from the umbilical cord, and 67 control patients. In a case-control study, Barczewska and colleagues studied the safety and efficacy of three intrathecal injections of umbilical cord mesenchymal stem cells in ALS patients 10. Data from clinical trials show that intrathecal injections of bone marrow mesenchymal stem cells slow the progression of ALS based on evaluations of changes in ALSFRS-R, (ALS Functional Rating Scale Revised) in ALS patients 8,9. This involves extracting bone marrow from the patient, isolating and culturing MSCs, mixing them with cerebrospinal fluid, CSF collected and administering the final product into the CSF, by a so-called intrathecal injection. The treatment is based on autologous mesenchymal stem cells from the bone marrow. In 2014, the first stem cell therapy for the treatment of ALS was launched in South Korea. Most of them are phase I/II studies to show safety in transplantation, but some progress has already been observed 5-7. Many clinical trials have been performed on ALS patients especially with MSC from bone marrow. The immunomodulatory properties of MSCs also play an important role in the treatment of inflammatory diseases, including neurodegenerative diseases. In recent years, mesenchymal stem cells, MSCs have been recognized as a potential candidate in cell therapy of neurodegenerative diseases, due to their regenerative properties. There is currently only one approved drug in Europe, Riluzol®, which can prolong survival by 3 months 4. The mechanisms by which ALS develops are not completely mapped, but disease mechanisms may include both glial cells and nerve cells 3. Death usually occurs within 5 years of diagnosis and is mainly due to paralysis of the respiratory muscles 2. Clinical symptoms consist of a gradual weakening and atrophy of muscles. ALS affect the nerve cells that control voluntary muscle movements, such as walking and talking, swallowing and breathing (motor neurons) 1. Every year, just over 200 people are diagnosed with the disease in Sweden. Amyotrophic Lateral Sclerosis, (ALS) is a serious but unusual neurodegenerative disease, for which there is currently no cure.
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